Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration
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چکیده
منابع مشابه
Basal Forebrain Neuronal Loss in Mice Lacking Neurotrophin Receptor p75
There is substantial evidence from in vitro studies that nerve growth factor (NGF) exerts an important influence on the development and survival of central neurons (1). The effects of NGF are thought to be mediated through the high-affinity tyrosine receptor kinase trkA and the low-affinity p75 receptor (2). Several studies suggest that the p75 receptor initiates an apoptotic signal that leads ...
متن کاملBasal forebrain neuronal loss in mice lacking neurotrophin receptor p75.
There is substantial evidence from in vitro studies that nerve growth factor (NGF) exerts an important influence on the development and survival of central neurons (1). The effects of NGF are thought to be mediated through the high-affinity tyrosine receptor kinase trkA and the low-affinity p75 receptor (2). Several studies suggest that the p75 receptor initiates an apoptotic signal that leads ...
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1 2 3 4 5 6 Neuron-specific cholinergic modulation of a forebrain song control nucleus 7 8 Stephen D. Shea1, Henner Koch2, Daniel Baleckaitis2, Jan-Marino Ramirez1,2 and Daniel 9 Margoliash1,2 10 11 1Committee on Neurobiology 12 2Department of Organismal Biology and Anatomy 13 University of Chicago 14 1027 E. 57th Street 15 Chicago, IL 60637 16 17 18 Running head: Neuron-specific cholinergic mo...
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Alzheimer's disease (AD) is characterized by progressive cognitive impairment associated with marked cholinergic neuron loss and amyloid-β (Aβ) peptide accumulation in the brain. The cytotoxicity in AD is mediated, at least in part, by Aβ binding with the extracellular domain of the p75 neurotrophin receptor (p75NTR), localized predominantly in the membranes of acetylcholine-producing neurons i...
متن کاملNeuron-specific cholinergic modulation of a forebrain song control nucleus.
Cholinergic activation profoundly affects vertebrate forebrain networks, but pathway, cell type, and modality specificity remain poorly understood. Here we investigated cell-specific cholinergic modulation of neurons in the zebra finch forebrain song control nucleus HVC using in vitro whole cell recordings. The HVC contains projection neurons that exclusively project to either another song moto...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-41654-8